As time progresses, we’ll all (hopefully) experience the beauty of aging. How quickly we age and aging’s impact on our mental and physical health is related to multiple factors including lifestyle, stress, pollution, infection, disease and more.
Ultimately, aging boils down to how the smallest units of ourselves — our cells — function.
Cellular stress and accelerated aging
The cell is our most basic building block. Our cells are full of activity, from energy production and metabolism to cell signaling and DNA replication, and so much more. But, these highly active cells can get damaged or sluggish. If this happens to enough cells, we start to see signs of dysfunction on an organ level. The heart pumps less, blood vessels harden, metabolism gets sluggish, skin loses structure and bones weaken.
There’s a constant battle between cellular stressors and our body’s protective mechanisms. How well the cells deal with this fight determines our physiologic age — the age of our organs and how efficiently our bodies run.
What is NAD+?
Aging researchers have identified a mighty molecule called NAD+ or nicotinamide adenine dinucleotide. This molecule initiates and assists in hundreds of metabolic reactions in the cell. It acts as a fuel source to help cells break down food, remove toxins, replicate and produce more energy1.
NAD+ levels decline with age. This means our cells’ ability to make cellular energy (called ATP) becomes less effective, while their ability to protect against or repair damage goes down. It is the disturbance of this balance that results in a host of diseases including inflammation and reduced cardiovascular and cognitive capacity.
One way we can directly increase NAD+ levels is through vitamin B3, which is a precursor to NAD+. Particularly, the vitamin B3 form called nicotinamide mononucleotide (NMN). NMN can provide a constant supply of NAD+, which means that cells can continue to function for longer2.
Keeping our cells clean
Another important process for healthy cellular functioning is making sure our cells stay clean and organized. Like a busy household, molecules come in and out, and waste gets produced in the cells. You want to make sure good housekeeping functions are in place. Housekeeping in the cell is called autophagy. However, the signals and processes for autophagy 3 decline as we age.
Particular foods have been seen to restart cellular autophagy including vegetable sprouts, cheese, peas, natto, soy, wheat germ, fermented foods and various citrus fruits. All of these foods have high levels of polyamines. Polyamines shield DNA from damage and turn on the signals to get our cellular housekeeping genes going4. An example of a polyamine is spermidine, which is found in wheat germ. Spermidine has been shown to help cell growth, cell repair and cellular clean up5. AOR is the first company to combine these powerful molecules.
Boost NAD+ levels and increase polyamine consumption in one supplement with NMN + Wheat Germ to keep your cells functioning for longer.
- Niu, K. M., Bao, T., Gao, L., Ru, M., Li, Y., Jiang, L., Ye, C., Wang, S., & Wu, X. (2021). The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase. Frontiers in nutrition, 8, 756243. https://doi.org/10.3389/fnut.2021.756243https://doi.org/10.3389/fnut.2021.756243
- Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell metabolism, 27(3), 513–528. https://doi.org/10.1016/j.cmet.2017.11.002
- Tabibzadeh, S. (2023). Role of autophagy in aging: The good, the bad, and the ugly. Aging Cell, 22, e13753. https://doi.org/10.1111/acel.13753
- Soda K. Overview of Polyamines as Nutrients for Human Healthy Long Life and Effect of Increased Polyamine Intake on DNA Methylation. Cells. 2022 Jan 4;11(1):164. doi: 10.3390/cells11010164. PMID: 35011727; PMCID: PMC8750749.
- Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. PMID: 30306826; PMCID: PMC6287690.
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